A novel monoclonal antibody effective against lethal challenge with swine-lineage and 2009 pandemic H1N1 influenza viruses in mice
Identifieur interne : 000C92 ( Main/Exploration ); précédent : 000C91; suivant : 000C93A novel monoclonal antibody effective against lethal challenge with swine-lineage and 2009 pandemic H1N1 influenza viruses in mice
Auteurs : Hongxia Shao [République populaire de Chine, États-Unis] ; Jianqiang Ye [États-Unis] ; Amy L. Vincent [États-Unis] ; Nicole Edworthy [États-Unis] ; Andrea Ferrero [États-Unis] ; Aijian Qin [République populaire de Chine] ; Daniel R. Perez [États-Unis]Source :
- Virology [ 0042-6822 ] ; 2011.
Abstract
The HA protein of the 2009 pandemic H1N1viruses (H1N1pdm) is antigenically closely related to the HA of classical North American swine H1N1 influenza viruses (cH1N1). Since 1998, through mutation and reassortment of HA genes from human H3N2 and H1N1 influenza viruses, swine influenza strains are undergoing substantial antigenic drift and shift. In this report we describe the development of a novel monoclonal antibody (S-OIV-3B2) that shows high hemagglutination inhibition (HI) and neutralization titers against not only H1N1pdm, but also against representatives of the α, β, and γ clusters of swine-lineage H1 influenza viruses. Mice that received a single intranasal dose of S-OIV-3B2 were protected against lethal challenge with either H1N1pdm or cH1N1 virus. These studies highlight the potential use of S-OIV-3B2 as effective intranasal prophylactic or therapeutic antiviral treatment for swine-lineage H1 influenza virus infections.
Url:
DOI: 10.1016/j.virol.2011.06.021
PubMed: 21774955
PubMed Central: 3180849
Affiliations:
- République populaire de Chine, États-Unis
- Iowa, Maryland
- College Park (Maryland)
- Université du Maryland
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Le document en format XML
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Perez</name><affiliation wicri:level="4"><nlm:aff id="A2">Department of Veterinary Medicine, University of Maryland, College Park and Virginia-Maryland Regional College of Veterinary Medicine. 8075 Greenmead Drive, College Park, MD 20742, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Veterinary Medicine, University of Maryland, College Park and Virginia-Maryland Regional College of Veterinary Medicine. 8075 Greenmead Drive, College Park, MD 20742</wicri:regionArea><placeName><region type="state">Maryland</region><settlement type="city">College Park (Maryland)</settlement></placeName><orgName type="university">Université du Maryland</orgName></affiliation></author></analytic><series><title level="j">Virology</title><idno type="ISSN">0042-6822</idno><idno type="eISSN">1096-0341</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">The HA protein of the 2009 pandemic H1N1viruses (H1N1pdm) is antigenically closely related to the HA of classical North American swine H1N1 influenza viruses (cH1N1). Since 1998, through mutation and reassortment of HA genes from human H3N2 and H1N1 influenza viruses, swine influenza strains are undergoing substantial antigenic drift and shift. In this report we describe the development of a novel monoclonal antibody (S-OIV-3B2) that shows high hemagglutination inhibition (HI) and neutralization titers against not only H1N1pdm, but also against representatives of the α, β, and γ clusters of swine-lineage H1 influenza viruses. Mice that received a single intranasal dose of S-OIV-3B2 were protected against lethal challenge with either H1N1pdm or cH1N1 virus. These studies highlight the potential use of S-OIV-3B2 as effective intranasal prophylactic or therapeutic antiviral treatment for swine-lineage H1 influenza virus infections.</p></div></front></TEI><affiliations><list><country><li>République populaire de Chine</li><li>États-Unis</li></country><region><li>Iowa</li><li>Maryland</li></region><settlement><li>College Park (Maryland)</li></settlement><orgName><li>Université du Maryland</li></orgName></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Shao, Hongxia" sort="Shao, Hongxia" uniqKey="Shao H" first="Hongxia" last="Shao">Hongxia Shao</name></noRegion><name sortKey="Qin, Aijian" sort="Qin, Aijian" uniqKey="Qin A" first="Aijian" last="Qin">Aijian Qin</name></country><country name="États-Unis"><region name="Maryland"><name sortKey="Shao, Hongxia" sort="Shao, Hongxia" uniqKey="Shao H" first="Hongxia" last="Shao">Hongxia Shao</name></region><name sortKey="Edworthy, Nicole" sort="Edworthy, Nicole" uniqKey="Edworthy N" first="Nicole" last="Edworthy">Nicole Edworthy</name><name sortKey="Ferrero, Andrea" sort="Ferrero, Andrea" uniqKey="Ferrero A" first="Andrea" last="Ferrero">Andrea Ferrero</name><name sortKey="Perez, Daniel R" sort="Perez, Daniel R" uniqKey="Perez D" first="Daniel R." last="Perez">Daniel R. Perez</name><name sortKey="Vincent, Amy L" sort="Vincent, Amy L" uniqKey="Vincent A" first="Amy L" last="Vincent">Amy L. Vincent</name><name sortKey="Ye, Jianqiang" sort="Ye, Jianqiang" uniqKey="Ye J" first="Jianqiang" last="Ye">Jianqiang Ye</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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